Synaptic plasticity
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In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory).
The correlative Hebbian synaptic plasticity theory is one of the most influential ideas about the changes that may occur in the brain as it takes in new information. If cell A is frequently taking part in firing cell B, then the strength of their connection should increase. The increase in strength is based on causality and repetition between individual neurons within a neuronal population. The underlying factor is that the synapse is responsible for correct responses.
Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse. There are several underlying mechanisms that cooperate to achieve synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and changes in how effectively cells respond to those neurotransmitters. Synaptic plasticity in both excitatory and inhibitory synapses has been found to be dependent upon postsynaptic calcium release.
How this connects to Neuroscience
Nervous-system function depends on localized pathways and distributed networks. The timing, distribution and combination of sensory, motor, cognitive or autonomic findings inform localization, while structural imaging, electrophysiology and the clinical examination provide different forms of evidence.
Text credit: Wikipedia contributors, “Synaptic plasticity”, original article · authors & revision history · CC BY-SA 4.0. Unmodified opening extract, accessed 24 September 2026. This Wikipedia-derived section is provided under CC BY-SA 4.0; the independent MedAtlas notes and design are separate works.
Synaptic plasticity · visual study map
Scalable vector illustration. Labeled conceptual map, not a precise anatomical, histological or diagnostic image.The wording in this learning map is adapted from the attributed Wikipedia background section below (CC BY-SA 4.0).
What the underlying subject studies
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How mechanisms and evidence connect
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How to develop a sound explanation
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