MBBS · Physiology

Respiratory mechanics

Ventilation moves air because respiratory muscle activity changes thoracic volume and therefore pressure. Gas exchange occurs across the alveolar–capillary barrier.

Open interactive lesson & self-check ↗

Alveolar gas exchange

Original conceptual SVG · scalable
ALVEOLUSair-filled spaceO₂CO₂Thin alveolar–capillary barrierPulmonary capillary bloodVentilation ≠ perfusion

Partial-pressure gradients move O₂ into pulmonary capillary blood and CO₂ toward alveolar gas; schematic, not to scale.

Concept 01

Mechanics of inspiration

Contraction of the diaphragm increases thoracic volume and lowers alveolar pressure relative to atmospheric pressure, drawing air inward during quiet inspiration.

Concept 02

Gas exchange

Oxygen diffuses from alveolar air toward pulmonary capillary blood, while carbon dioxide diffuses in the opposite direction, according to partial-pressure gradients.

Concept 03

Separate terms

Ventilation is air movement, perfusion is blood flow, diffusion is gas transfer. Ventilation–perfusion mismatch can impair arterial oxygenation.

Education / safety note: The alveolar illustration is not to scale; the alveolar–capillary interface is a thin, highly specialized exchange surface.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: OpenStax Anatomy and Physiology 2e (read on publisher site) ↗Official / publisher source: PubMed ↗