MBBS · Physiology

Homeostasis and feedback

Homeostasis describes regulation of internal variables around physiological operating ranges. Negative feedback opposes a disturbance rather than erasing all variation.

Open interactive lesson & self-check ↗

Negative feedback loop

Original conceptual SVG · scalable
Regulated variablee.g. core temperatureSensordetects changeControl centerintegrates feedbackEffectoropposes changeExample: warming → sweating → cooling

A disturbance changes a regulated variable; sensor, controller and effector coordinate a corrective response.

Concept 01

Identify the loop

A sensor detects a regulated variable. A control center compares information with physiological requirements. Effectors change the variable.

Concept 02

Use thermoregulation as an example

When core temperature rises, heat-loss mechanisms such as skin vasodilation and sweating contribute to cooling. When temperature falls, conservation and heat production are increased.

Concept 03

Distinguish feedback types

Negative feedback reduces deviation. Positive feedback amplifies a process until an external event or limiting mechanism ends it; it is not the usual mechanism for stable regulation.

Education / safety note: The set-point analogy is a simplification; many controlled variables use dynamic ranges and interacting regulators.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: OpenStax Anatomy and Physiology 2e (read on publisher site) ↗Official / publisher source: PubMed ↗