MBBS · Physiology

Action potential

An action potential is a regenerative change in membrane voltage, produced by time-dependent opening and inactivation of voltage-gated ion channels.

Open interactive lesson & self-check ↗

Typical neuronal action potential

Original conceptual SVG · scalable
Time →VoltagerestNa⁺ influxK⁺-dependentrepolarizationafter-hyperpolarizationthreshold

Illustrative voltage-versus-time trace; not calibrated. Cardiac pacemaker cells have different mechanisms.

Concept 01

Resting state

Ion gradients, selective membrane permeability and active pumps support resting electrical potential; values vary by cell type.

Concept 02

Rising phase

In a typical excitable axon, reaching threshold opens voltage-gated sodium channels and sodium influx depolarizes the membrane.

Concept 03

Recovery phase

Sodium-channel inactivation and potassium conductance contribute to repolarization; refractory periods support directional propagation along normal pathways.

Education / safety note: Not all excitable tissues use the same ion channels or waveform; cardiac nodal action potentials differ from a typical neuronal axon.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: OpenStax Anatomy and Physiology 2e (read on publisher site) ↗Official / publisher source: PubMed ↗