MBBS · Physiology

Acid-base balance

Acid–base homeostasis integrates chemical buffers, carbon dioxide elimination and renal bicarbonate handling. Interpret pH, carbon dioxide and bicarbonate together rather than separately.

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Acid-base balance — learning map

Original conceptual SVG · scalable
LABELED RELATIONSHIP MAP · SCHEMATIC, NOT TO SCALEBufferingrapid chemical responseRespiratory controlminutes to hoursRenal controlhours to daysCompensationresponse not cureAcid-base balanceKEY RELATIONSHIPS

Original schematic relationship map for this topic; relationships are organized for study, not intended as an anatomical depiction or a diagnostic algorithm.

Concept 01

Buffering

Bicarbonate and nonbicarbonate buffers reduce abrupt changes in hydrogen ion concentration.

Concept 02

Respiratory control

Alveolar ventilation changes arterial carbon dioxide, influencing the carbonic-acid component of the extracellular buffer system.

Concept 03

Renal control

Kidneys reclaim filtered bicarbonate and generate new bicarbonate while excreting acid as ammonium and titratable acids.

Concept 04

Compensation

A primary respiratory or metabolic disturbance may trigger compensation in the other system, but compensation does not necessarily restore pH fully.

Education / safety note: This is not a blood-gas interpretation calculator or a substitute for evaluating an acutely ill patient.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: NCBI Bookshelf ↗Official / publisher source: PubMed ↗