MBBS · Biochemistry

Oxidative phosphorylation

Oxidative phosphorylation couples electron transfer through respiratory-chain complexes to ATP generation across the inner mitochondrial membrane.

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Oxidative phosphorylation — learning map

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LABELED RELATIONSHIP MAP · SCHEMATIC, NOT TO SCALEElectron donorsNADH and FADH₂Proton gradientelectrochemical energyATP synthasegradient to ATPCoupling and heatefficiency variesOxidative phosphorylationKEY RELATIONSHIPS

Original schematic relationship map for this topic; relationships are organized for study, not intended as an anatomical depiction or a diagnostic algorithm.

Concept 01

Electron donors

Reduced cofactors donate electrons to the chain; molecular oxygen is the terminal electron acceptor and is reduced to water.

Concept 02

Proton gradient

Electron transport pumps protons across the inner mitochondrial membrane, producing an electrochemical gradient.

Concept 03

ATP synthase

Protons returning through ATP synthase drive conformational changes that support ADP phosphorylation to ATP.

Concept 04

Coupling and heat

Proton leaks, uncoupling and substrate availability influence the amount of ATP produced per oxygen consumed.

Education / safety note: Poisons and inherited respiratory-chain diseases can disrupt this system; this chapter is not a poisoning management resource.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: NCBI Bookshelf ↗Official / publisher source: PubMed ↗