MBBS · Biochemistry

Enzymes and kinetics

Enzymes accelerate reactions by stabilizing lower-energy reaction pathways without shifting the overall equilibrium of a reversible reaction.

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Enzymes and kinetics — learning map

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LABELED RELATIONSHIP MAP · SCHEMATIC, NOT TO SCALECatalysislower activation barrierMichaelis–Menten behaviorsimple saturation modelCompetitive inhibitionsubstrate competitionAllosteric regulationnot every enzyme is MMEnzymes and kineticsKEY RELATIONSHIPS

Original schematic relationship map for this topic; relationships are organized for study, not intended as an anatomical depiction or a diagnostic algorithm.

Concept 01

Catalysis

An enzyme active site binds substrates and stabilizes transition states, increasing reaction rate while remaining regenerated at the end.

Concept 02

Michaelis–Menten behavior

For applicable single-substrate systems, velocity approaches Vmax as substrate concentration rises; Km is the substrate concentration at half Vmax under model assumptions.

Concept 03

Competitive inhibition

A classic competitive inhibitor raises apparent Km without changing Vmax when sufficient substrate can overcome inhibitor binding.

Concept 04

Allosteric regulation

Multisubunit enzymes may show cooperative or complex kinetics, so a simple hyperbola does not capture all biological regulation.

Education / safety note: Km is not universally identical to binding affinity; enzyme kinetics depend on mechanism and assay conditions.

Reference and next reading

Explore the original curriculum and publisher-hosted resources for full-depth reading; this note is an original schematic introduction, not an exhaustive chapter.

Official / publisher source: NMC official CBME Curriculum 2024 and current regulations index ↗Official / publisher source: NCBI Bookshelf ↗Official / publisher source: PubMed ↗